Helios 15S is an ion-exchange resin based on highly cross-linked porous polystyrene-divinylbenzene (PS/DVB) monodisperse microspheres, and chemical compounds are bonded to the surface of the microspheres producing a highly stable hydrophilic layer. Helios 15S has the characteristics of high flow rate, high resolution, high capacity, high rigidity, good biocompatibility, and physical and chemical stability. Compared with traditional chromatography resin, it significantly improves the production efficiency and sample recovery rate of the downstream purification process, and is widely used in the capture, intermediate purification and fine purification of biomolecules such as antibodies, proteins, peptides and nucleic acids.